翻訳と辞書
Words near each other
・ Corigliano Calabro
・ Corigliano d'Otranto
・ Corigliano Quartet
・ Corignac
・ Coriile Mari River
・ Coriile Mici River
・ Corilagin
・ Corilair
・ Corilla
・ Corima
・ Corimbat River
・ Corimbion
・ Corey–Fuchs reaction
・ Corey–House synthesis
・ Corey–Itsuno reduction
Corey–Kim oxidation
・ Corey–Link reaction
・ Corey–Winter olefin synthesis
・ Core–mantle boundary
・ Core–shell semiconductor nanocrystal
・ Corf
・ Corf (disambiguation)
・ Corf (mining)
・ Corf county campsite
・ Corfe
・ Corfe & Barrow Hills
・ Corfe (surname)
・ Corfe Castle
・ Corfe Castle (disambiguation)
・ Corfe Castle (UK Parliament constituency)


Dictionary Lists
翻訳と辞書 辞書検索 [ 開発暫定版 ]
スポンサード リンク

Corey–Kim oxidation : ウィキペディア英語版
Corey–Kim oxidation

The Corey–Kim oxidation is an oxidation reaction used to synthesise aldehydes and ketones from primary and secondary alcohols.〔
〕 It is named for American chemist and Nobelist Elias James Corey and Korean-American chemist Choung Un Kim.
Although the Corey–Kim oxidation possesses the distinctive advantage over Swern oxidation of allowing an operation above –25 °C, it is not so commonly used due to issues with selectivity in substrates susceptible to chlorination by ''N''-chlorosuccinimide.
==Reaction mechanism==

Dimethyl sulfide (Me2S) is treated with ''N''-chlorosuccinimide (NCS), resulting in formation of an "active DMSO" species that is used for the activation of the alcohol. Addition of triethylamine to the activated alcohol leads to its oxidation to aldehyde or ketone and generation of dimethyl sulfide. In variance with other alcohol oxidation using "activated DMSO," the reactive oxidizing species is not generated by reaction of DMSO with an electrophile. Rather, it is formed by oxidation of dimethyl sulfide with an oxidant (NCS).
Under Corey–Kim conditions allylic and benzylic alcohols have a tendency to evolve to the corresponding allyl and benzyl chlorides unless the alcohol activation is very quickly followed by addition of triethylamine. In fact, Corey–Kim conditions —with no addition of triethylamine— are very efficient for the transformation of allylic and benzylic alcohols to chlorides in presence of other alcohols.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Corey–Kim oxidation」の詳細全文を読む



スポンサード リンク
翻訳と辞書 : 翻訳のためのインターネットリソース

Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.